However, when it comes to application programs, machine dependency is a high price to pay for efficiency, so application programs are rarely written in assembler. 然而，当它应用于应用程序时，依赖于机器的属性是要为效率付出高代价的，所以应用程序很少用汇编语言来写。
Because of the one-to-one relationship between the language and the machine, assemblers are machine dependent, and a program written for one type of computer won't run on another. 因为汇编指令和机器指令之间存在一一对应的关系，汇编语言和机器语言都是依赖于机器的，所以为一种型号计算机编写的程序不能在另一种型号的机器上执行。
